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Mechanisms of “kidney governing bones” theory in traditional Chinese medicine

Dahong Ju,Meijie Liu,Hongyan Zhao,Jun Wang

Frontiers of Medicine 2014, Volume 8, Issue 3,   Pages 389-393 doi: 10.1007/s11684-014-0362-y

Abstract:

Studies conducted by our group on the mechanism of “kidney governing bones” theory in” Although kidney-reinforcing therapy is regarded as one of the holistic regulatory mechanisms” Kidney deficiency refers to a deficiency in only one or more units of the kidney system and notAlthough both classified as kidney-reinforcing agents, the former can resolve failure of the “kidney;kidney governing bones” remains complicated and unresolved.

Keywords： kidney governing bones     kidney deficiency     marrow     osteoporosis     neuroendocrine-immune network     osteoclast    

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Antithrombin deficiency and decreased protein C activity in a young man with venous thromboembolism:

Dong Wang, Min Tian, Guanglin Cui, Dao Wen Wang

Frontiers of Medicine 2018, Volume 12, Issue 3,   Pages 319-323 doi: 10.1007/s11684-017-0553-4

Abstract: Mutations in and lead to deficiency or dysfunction of the two proteins, which could result in venousCoagulation tests revealed that the patient presented type I antithrombin deficiency combined with decreasedThis study demonstrates that the combination of antithrombin deficiency and decreased protein C activity

Keywords： antithrombin deficiency     protein C activity     mutation     variant     venous thromboembolism     anticoagulants    

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Dynein axonemal heavy chain 10 deficiency causes primary ciliary dyskinesia in humans and mice

Frontiers of Medicine   Pages 957-971 doi: 10.1007/s11684-023-0988-8

Abstract: To the best of our knowledge, this study is the first to report DNAH10 deficiency related to PCD

Keywords： DNAH10     mice     motile cilia     mutation     primary ciliary dyskinesia    

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Normoalbuminuric diabetic kidney disease

Chao Chen, Chang Wang, Chun Hu, Yachun Han, Li Zhao, Xuejing Zhu, Li Xiao, Lin Sun

Frontiers of Medicine 2017, Volume 11, Issue 3,   Pages 310-318 doi: 10.1007/s11684-017-0542-7

Abstract:

Diabetic kidney disease (DKD) is one of the primary causes of end-stage renal disease (ESRD).with normoalbuminuria have progressive renal insufficiency, referred to as normoalbuminuric diabetic kidneyEpidemiologic research has demonstrated that normoalbuminuric diabetic kidney disease is common, and

Keywords： diabetes     diabetic kidney disease     normoalbuminuria     renal impairment    

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Successful kidney transplantation in highly sensitized patients

Weijie ZHANG, Dong CHEN, Zhishui CHEN, Fanjun ZENG, Changsheng MING, Zhengbin LIN, Ping ZHOU, Gang CHEN, Xiaoping CHEN

Frontiers of Medicine 2011, Volume 5, Issue 1,   Pages 80-85 doi: 10.1007/s11684-011-0115-0

Abstract: This study reports our experience in kidney transplantation in highly sensitized patients.desensitization using PP/IVIG with or without rituximab increases the likelihood of successful live-donor kidney

Keywords： Kidney transplantation     desensitization    

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Risk factors of prognosis after acute kidney injury in hospitalized patients

Sasa Nie, Zhe Feng, Lihua Xia, Jiuxu Bai, Fenglin Xiao, Jian Liu, Li Tang, Xiangmei Chen

Frontiers of Medicine 2017, Volume 11, Issue 3,   Pages 393-402 doi: 10.1007/s11684-017-0532-9

Abstract:

The risk factors, especially laboratory indicators, of prognosis after acute kidney injury (AKI) remainHospital from January 1, 2012 to December 31, 2012 according to the AKI diagnosis standard issued by Kidney

Keywords： acute kidney injury     risk factors     prognosis    

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Effect of renal function and hemodialysis on the serum tumor markers in patients with chronic kidney

YU Xiaofang, XU Xialian, YE Zhibin

Frontiers of Medicine 2007, Volume 1, Issue 3,   Pages 308-311 doi: 10.1007/s11684-007-0059-6

Abstract: corresponding tumors is decreased while others remain as valuable as they are in patients with normal kidneyIt has been recently shown that some tumor markers are higher in patients with chronic kidney diseasedecreased while serum AFP, CA, CA, PSA and fPSA were as valuable as they were in patients with normal kidney

Keywords： CKD     non-dialysis     valuable     detection     chronic    

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Prevalence of vitamin D deficiency in girls with idiopathic central precocious puberty

Yue Zhao, Wenjun Long, Caiqi Du, Huanhuan Yang, Shimin Wu, Qin Ning, Xiaoping Luo

Frontiers of Medicine 2018, Volume 12, Issue 2,   Pages 174-181 doi: 10.1007/s11684-017-0544-5

Abstract:

The relationship between vitamin D deficiency and idiopathic central precocious puberty (ICPP) hasThe ICPP subjects with 25[OH]D deficiency had a higher body mass index (BMI) than the subjects from the

Keywords： idiopathic central precocious puberty     threshold effects     vitamin D status    

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Netrin-1 works with UNC5B to regulate angiogenesis in diabetic kidney disease

Xiaojing Jiao, Dong Zhang, Quan Hong, Lei Yan, Qiuxia Han, Fengmin Shao, Guangyan Cai, Xiangmei Chen, Hanyu Zhu

Frontiers of Medicine 2020, Volume 14, Issue 3,   Pages 293-304 doi: 10.1007/s11684-019-0715-7

Abstract: This study examined netrin-1 and UNC5B expression in kidneys with diabetic kidney disease (DKD) and investigatedendogenous UNC5B are potential strategies for reducing the incidence of early angiogenesis and mitigating kidney

Keywords： netrin-1     VEGF-165     UNC5B     angiogenesis     diabetic kidney disease    

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Identification of differentially expressed miRNAs associated with chronic kidney disease–mineral bone

Kyung Im Kim, Sohyun Jeong, Nayoung Han, Jung Mi Oh, Kook-Hwan Oh, In-Wha Kim

Frontiers of Medicine 2017, Volume 11, Issue 3,   Pages 378-385 doi: 10.1007/s11684-017-0541-8

Abstract: purpose of this study is to characterize a meta-signature of differentially expressed mRNA in chronic kidney

Keywords： chronic kidney disease     microRNA     mineral bone disorder     uremia    

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non-inferiority trial of intravenous ferric carboxymaltose versus iron sucrose in patients with iron deficiency

Frontiers of Medicine doi: 10.1007/s11684-023-1001-2

Abstract: Iron deficiency (ID) and ID anemia (IDA) pose significant public health concerns in China.

Keywords： iron deficiency     anemia     intravenous iron     ferric carboxymaltose     iron sucrose     Hb response     early response    

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Intestinal Epithelial Axin1 Deficiency Protects Against Colitis via Altered Gut Microbiota

Shari Garrett,Yongguo Zhang,Yinglin Xia,Jun Sun,

Engineering doi: 10.1016/j.eng.2023.06.007

Abstract: Intestinal homeostasis is maintained by specialized host cells and the gut microbiota. Wnt/β-catenin signaling is essential for gastrointestinal development and homeostasis, and its dysregulation has been implicated in inflammation and colorectal cancer. Axin1 negatively regulates activated Wnt/β-catenin signaling, but little is known regarding its role in regulating host–microbial interactions in health and disease. Here, we aim to demonstrate that intestinal Axin1 determines gut homeostasis and host response to inflammation. Axin1 expression was analyzed in human inflammatory bowel disease datasets. To explore the effects and mechanism of intestinal Axin1 in regulating intestinal homeostasis and colitis, we generated new mouse models with Axin1 conditional knockout in intestinal epithelial cell (IEC; Axin1ΔIEC) and Paneth cell (PC; Axin1ΔPC) to compare with control (Axin1LoxP; LoxP: locus of X-over, P1) mice. We found increased Axin1 expression in the colonic epithelium of human inflammatory bowel disease (IBD). Axin1ΔIEC mice exhibited altered goblet cell spatial distribution, PC morphology, reduced lysozyme expression, and enriched Akkermansia muciniphila (A. muciniphila). The absence of intestinal epithelial and PC Axin1 decreased susceptibility to dextran sulfate sodium-induced colitis in vivo. Axin1ΔIEC and Axin1ΔPC mice became more susceptible to dextran sulfate sodium (DSS)-colitis after cohousing with control mice. Treatment with A. muciniphila reduced DSS-colitis severity. Antibiotic treatment did not change the IEC proliferation in the Axin1Loxp mice. However, the intestinal proliferative cells in Axin1ΔIEC mice with antibiotic treatment were reduced compared with those in Axin1ΔIEC mice without treatment. These data suggest non-colitogenic effects driven by the gut microbiome. In conclusion, we found that the loss of intestinal Axin1 protects against colitis, likely driven by epithelial Axin1 and Axin1-associated A. muciniphila. Our study demonstrates a novel role of Axin1 in mediating intestinal homeostasis and the microbiota. Further mechanistic studies using specific Axin1 mutations elucidating how Axin1 modulates the microbiome and host inflammatory response will provide new therapeutic strategies for human IBD.

Keywords： Axin1     Bacteria     Microbiome inflammation     Inflammatory bowel disease     Immunity     Microbiome     Paneth cells     Akkermansia muciniphila     Wnt    

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Chinmedomics facilitated quality-marker discovery of Sijunzi decoction to treat spleen qi deficiency

Qiqi Zhao, Xin Gao, Guangli Yan, Aihua Zhang, Hui Sun, Ying Han, Wenxiu Li, Liang Liu, Xijun Wang

Frontiers of Medicine 2020, Volume 14, Issue 3,   Pages 335-356 doi: 10.1007/s11684-019-0705-9

Abstract: Sijunzi decoction (SJZD) is a Chinese classical formula to treat spleen qi deficiency syndrome (SQDS)

Keywords： traditional Chinese medicine     Sijunzi decoction     spleen qi deficiency syndrome     Chinmedomics     quality-marker    

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Leading Approaches to Vascularize Kidney Constructs in Tissue Engineering Review

Diana S. Lim, John D. Jackson, Anthony Atala, James J. Yoo

Engineering 2022, Volume 19, Issue 12,   Pages 117-127 doi: 10.1016/j.eng.2022.05.004

Abstract: Kidney tissue engineering approaches promise to develop alternative solutions that address many of therecellularization approaches, microscale organogenesis, and vascularization using organoids in the context of kidney

Keywords： Kidney     Vascularization     Tissue engineering     Biofabrication     Organoids    

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similar characteristics can be isolated from human fetal bone marrow, heart, liver, muscle, lung, derma, kidney

FANG Baijun, SONG Yongping, LIN Quande, ZHAO Chunhua, SHI Mingxia

Frontiers of Medicine 2007, Volume 1, Issue 2,   Pages 185-191 doi: 10.1007/s11684-007-0035-1

Abstract: study, we further isolated pluripotent stem cells from human fetal heart, liver, muscle, lung, derma, kidney

Keywords： endothelial     phenomenon     ectodermal     Flk1CD34 postembryonic     irradiated non-obese    

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Title Author Date Type Operation

Mechanisms of “kidney governing bones” theory in traditional Chinese medicine

Dahong Ju,Meijie Liu,Hongyan Zhao,Jun Wang

Journal Article

Antithrombin deficiency and decreased protein C activity in a young man with venous thromboembolism:

Dong Wang, Min Tian, Guanglin Cui, Dao Wen Wang

Journal Article

Dynein axonemal heavy chain 10 deficiency causes primary ciliary dyskinesia in humans and mice

Journal Article

Normoalbuminuric diabetic kidney disease

Chao Chen, Chang Wang, Chun Hu, Yachun Han, Li Zhao, Xuejing Zhu, Li Xiao, Lin Sun

Journal Article

Successful kidney transplantation in highly sensitized patients

Weijie ZHANG, Dong CHEN, Zhishui CHEN, Fanjun ZENG, Changsheng MING, Zhengbin LIN, Ping ZHOU, Gang CHEN, Xiaoping CHEN

Journal Article

Risk factors of prognosis after acute kidney injury in hospitalized patients

Sasa Nie, Zhe Feng, Lihua Xia, Jiuxu Bai, Fenglin Xiao, Jian Liu, Li Tang, Xiangmei Chen

Journal Article

Effect of renal function and hemodialysis on the serum tumor markers in patients with chronic kidney

YU Xiaofang, XU Xialian, YE Zhibin

Journal Article

Prevalence of vitamin D deficiency in girls with idiopathic central precocious puberty

Yue Zhao, Wenjun Long, Caiqi Du, Huanhuan Yang, Shimin Wu, Qin Ning, Xiaoping Luo

Journal Article

Netrin-1 works with UNC5B to regulate angiogenesis in diabetic kidney disease

Xiaojing Jiao, Dong Zhang, Quan Hong, Lei Yan, Qiuxia Han, Fengmin Shao, Guangyan Cai, Xiangmei Chen, Hanyu Zhu

Journal Article

Identification of differentially expressed miRNAs associated with chronic kidney disease–mineral bone

Kyung Im Kim, Sohyun Jeong, Nayoung Han, Jung Mi Oh, Kook-Hwan Oh, In-Wha Kim

Journal Article

non-inferiority trial of intravenous ferric carboxymaltose versus iron sucrose in patients with iron deficiency

Journal Article

Intestinal Epithelial Axin1 Deficiency Protects Against Colitis via Altered Gut Microbiota

Shari Garrett,Yongguo Zhang,Yinglin Xia,Jun Sun,

Journal Article

Chinmedomics facilitated quality-marker discovery of Sijunzi decoction to treat spleen qi deficiency

Qiqi Zhao, Xin Gao, Guangli Yan, Aihua Zhang, Hui Sun, Ying Han, Wenxiu Li, Liang Liu, Xijun Wang

Journal Article

Leading Approaches to Vascularize Kidney Constructs in Tissue Engineering

Diana S. Lim, John D. Jackson, Anthony Atala, James J. Yoo

Journal Article

similar characteristics can be isolated from human fetal bone marrow, heart, liver, muscle, lung, derma, kidney

FANG Baijun, SONG Yongping, LIN Quande, ZHAO Chunhua, SHI Mingxia

Journal Article